Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation
Fig 6
Validation of the SRF under dynamic pacing conditions.
Results of 250 simulations for 20 different pacing conditions in which notable SCRE occurred. A– 100 examples (with one highlighted) of SCRE occurring in the 3D model (purple, i-iii) and 0D model (blue, iv-v) for two different conditions which resulted in SR-Ca2+ close to threshold (a, corresponding to Vent EPI, BCL = 400 ms, RCRU-CRU) and above it (b, corresponding to Vent ENDO, BCL = 400 ms, ISO + RSERCA/NCX). The linescans in (iii) correspond to the highlighted trace in (i-ii). Final paced beat and subsequent quiescent period is shown. B–Histograms of SCRE initiation time (left of each panel) and incidence of DADs and TA (bars, right of each panel) for the 20 different conditions (panel titles correspond to cell model, pre-pacing BCL and pro-SCRE conditions); the x-axis label for the histogram plots refers to the total range over which the plot is shown, rather than absolute values. Col. RA refers to the simplified Colman et al. 2013 [27] human atrial model; ORd refers to the simplified O’Hara et al. [26] human ventricular cell model; all other labels refer to the cell-type used in the hybrid minimal model presented in this study.