Non-ohmic tissue conduction in cardiac electrophysiology: Upscaling the non-linear voltage-dependent conductance of gap junctions
Fig 4
Impulse conduction features from computational simulations.
The propagating wavefront predicted by the CM clamped, CM voltage-gated, LHM and NOHM are compared for three levels of transjunctional coupling: (top row) high coupling β = 100%, (middle row) low coupling β = 10%, and (bottom row) very low couping β = 1%. In general, the LHM and NOHM drift ahead of their CM counterparts as the GJc is decreased in the case of instantaneous conductance. In contrast, for the case of steady-state conductance the NOHM accurately predicts the CM voltage-gated even for very low coupling levels, whereas the LHM substantially drifts ahead from the CM clamped wavefront.