β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology
Table 1
SOD1 Serine to BMAA mutation destabilizes SOD1 dimers.
Folding free energy differences between wild type and mutant SOD1, ΔΔG. Values are mean ± standard deviation among 20 independent runs. Calculations are performed using Eris with both fixed and flexible backbone algorithms for serine to BMAA, and to lysine, for comparison.