Aggressive or moderate drug therapy for infectious diseases? Trade-offs between different treatment goals at the individual and population levels
Fig 2
Transition from the nested agent-based model to an SIR model.
(A) Effect of treatment strength on the growth rate for the sensitive and resistant strains. At very high doses, neither strain can grow in the presence of treatment. (B) Mean recovery rates of an individual infected by the sensitive (blue) and resistant (red) strain. Simulated results are fitted with sigmoid functions. (C) Probability of emergence of resistance as a function of dose, obtained from 2 × 106 within-host simulations per dose (red) and fitted with the sum of two Gaussians (black).