Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy
Fig 9
Inter-patient variability in drug PK parameters.
The first line shows parameter variability across the considered patient population for irinotecan (A), oxaliplatin (B) and 5-fluorouracil (C), the colour and symbols represent the clusters each parameter set belongs to. The parameters are named with reference to the schematics of the models, the subscripts refer to the blood (B), organs (O) and liver (L). In the irinotecan parameters, additional subscripts cpt and sn refer to irinotecan and SN38 respectively. The second line shows multidimensional scaling representation of patient clustering based on their PK parameters for irinotecan (D), oxaliplatin (E) and 5-fluorouracil (F), the x refer to the cluster centroids and the points refer to patient PK parameters projected onto 2D plot.