Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy
Fig 3
Semi-physiological model of irinotecan PK.
Compartments were minimised to the most important components, Liver to accurately represent drug delivery, Blood which is measurement site and Organs to represent the rest of the body. Ci is the rate constant of clearance from compartment i. Irinotecan is bio-activated into its active metabolite SN38. Irinotecan was assumed to be delivered directly into the liver.