Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy
Fig 2
Improved administration profiles.
(A) shows the drug solution delivery profile which consists of an initial bolus to fill the tube entirely, followed by the original profile. (B) shows the rinse solution delivery rate which continues drug delivery at correct rate while clearing the tube from any active substance, Original rinse peaks were kept unchanged, although there are not mandatory in this administration design. (C) shows how the flow rate along the tube is smoothly switched between the drug and the rinse and (D) shows the new drug delivery profile that will enter the patient compared to the original profile used in the OPTILIV study.