Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling
Fig 6
The effects of treadmilling factor (χ) and myosin sliding on the morphologies of BAInit networks are illustrated.
Upper panel shows a cartoon of filaments (red) with barbed ends (black tips) representing various orientational arrangements that were realized in our simulations, determined by the interplay between the treadmilling rate and myosin activity. a-c) Representative final snapshots from simulations at M:A 0.0225 at various crosslinker mole ratio (α:A) at χ values 0.1 (a), 0.3 (b) and 1.0 (c) are shown. d) For networks with χ = 1.0, probability of finding NMIIA (dotted line) and α-actinin (solid line) along bundle axis are plotted.