Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling
Fig 4
Dendrograms illustrating clustering of different resultant actin network morphologies from either unipolar (left) or apolar (right) bundle initial configurations.
Distributions of distances between minus-minus, minus-plus and plus-minus ends were used to construct dissimilarity matrices for both unipolar and apolar cases. Agglomerative cluster trees were encoded from the above-mentioned dissimilarity matrices and then drawn as dendrograms. The three largest clusters are shown in red, blue and green along with representative final snapshots. α:A values are indicated close to the snapshots while M:A values are indicated for each sub-cluster. Clades corresponding to bundle-like configurations are colored in green while aster-like configurations are colored in blue. Intermediate states that do not resemble either network morphologies are colored in red.