Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data
Fig 13
Mutation accumulation plots showing the relationship between the mutation probability at position 55 across all sequences aligning closest to IGHV4-39*06 (y-axis), and the number of mutations in the entire observed V sequence (x-axis) for three simple, hypothetical BCR repertoires.
In the top row are two repertoires that consist of a single allele: where this allele is known (left), and where it is unknown, but separated by seven SNPs from a known allele (right). In a more typical case, given the relative completeness of the standard germline sets, we would observe a mixture of sequences from the known and unknown alleles (bottom). This is equivalent to the (shifted) superposition of the two plots in the top row.