Information-theoretic analysis of multivariate single-cell signaling responses
Fig 3
(A) A violin plot representation of the conditional output distribution Y|xi for 11 considered inputs. (B) Information capacity estimates as the function of the sample size N. Blue and red lines correspond to SLEMI and KNN estimates, respectively. The bold black line marks the true value of the capacity. For the KNN estimation, k = 10 was assumed. (C) Information capacity estimates of the KNN method as a function of k compared with the true value (bold black line). The error-bars in B and C show the standard deviation of capacity estimates from 40 repeated samplings. N = 1000 was assumed. (D) Computation time of SLEMI and KNN method as the function of the sample size N. (E) Computation time of SLEMI (blue) and the KNN method as the function of the number of considered input values. Input values were subsequently added starting with x1 and x2, only, and ending up with all 11 considered input values. The times reported in panels (D) and (E) correspond to computations performed by a single core on a workstation with Intel Xeon E5-1650 3.50 GHz processor and 32 GB RAM.