Information-theoretic analysis of multivariate single-cell signaling responses
Fig 2
Information-theoretic analysis of the NF-κB responses to TNF-α stimulation.
(A) Temporally resolved responses of individual cells to selected concentrations of TNF-α. The panel corresponds to Fig. IV in S1 Text. (B) The information capacity as a function of time for time-point responses. (C) As in (B) but for time-series responses. (D) Probabilities of the correct pairwise discrimination between TNF-α concentrations for time-point responses at 21 minutes. The color filled fraction of the circle marks the probability of correct discrimination. (E) The same as in (D) but for time-series responses. (F) Differences between probabilities in (D) and (E). Modeling details: Uncertainties of estimates (grey ribbons in B and C) were obtained by bootstrapping 80% of data (repeated 100 times). Probabilities in (D) and (E) present mean of 50 bootstrap re-sampling.