Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 7
Schematic outline of the PBPK model including four brain compartments (modified from Gaohua et al.) [8].
Qsin and Qsout represent CSF shuttle flow between cranial CSF and spinal CSF compartments. Qssink and Qcsink are the flows from CSF compartments to blood. Qbulk represents bulk flow from brain mass to cranial CSF. PSB, PSC and PSE represent permeability surface area products between brain blood and brain mass, brain blood and cranial CSF, and brain mass and cranial CSF, respectively. Subscripts lu, br, ad, bo, he, ki, mu, sk, li, re, gu, sp, ha denote lung, brain, adipose tissue, bone, heart, kidney, muscle, skin, liver, rest tissue, gut, spleen and hepatic artery, respectively. CL is the total clearance from the model. IV is an intravenous dose and oral is an oral dose route of administration.