Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 5
Simulations of pediatric concentration-time profiles for intravenous meropenem.
Simulations of plasma and CSF for patients suffering from sepsis (i.v. 20 mg/kg/8h) (A,B), or meningitis (i.v. 40 mg/kg/8h) (C,D). Solid black lines indicate simulated median profiles, the grey area represents 90% CI and dotted lines indicate the minimum and maximum simulation. Dots indicate measured data derived from clinical studies. Log-transformed results are depicted in the left upper corners.