Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 4
Simulations of adult concentration-time profiles for intravenous meropenem in meningitis patients.
Simulations of adult plasma and CSF concentration-time profiles (i.v. 1500 mg/8h) (A,B). Solid black lines indicate simulated median profiles, the grey area represents 90% CI and dotted lines indicate the minimum and maximum simulation. Dots indicate measured data derived from clinical studies. Log-transformed results are depicted in the left upper corners.