Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 3
Simulations of pediatric concentration-time profiles for ibuprofen, flurbiprofen and naproxen.
Simulations of oral ibuprofen (10 mg/kg in suspected sepsis patients) (A,B), IV ibuprofen (10 mg/kg in surgery patients) (C,D), IV flurbiprofen (0.9 mg/kg in surgery patients) (E,F), and oral naproxen (10 mg/kg in surgery patients) (G,H) concentration-time profiles. Solid black lines indicate simulation of median profiles, the grey area represents 90% CI and dotted lines indicate the minimum and maximum simulation. Dots indicate measured data derived from clinical studies. Log-transformed concentration-time data are depicted in the right upper corners (0 values were discarded).