Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 2
The effect of CSF production rate on paracetamol CSF concentration-time profiles.
The red lines indicate the simulations using the default CSF production rate. The black lines indicate a twofold increase or reduction in CSF production rate, respectively. The grey lines indicate a fivefold increase or reduction in CSF production rate, respectively.