Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis
Fig 1
Simulations of paracetamol concentration-time profiles.
Plasma and CSF concentration-time profiles of paracetamol after a single intravenous dose of 1000 mg in adults (A, B) and (15 mg/kg) (C,D) in children. Solid black lines indicate simulation of median profiles, the grey area represents 90% CI and dotted lines indicate the minimum and maximum simulation. Dots indicate measured data derived from clinical studies together with the reported S.E.M (adult) or individual observations (pediatric). Log-transformed results are depicted in the right upper corners.