Modeling the daily rhythm of human pain processing in the dorsal horn
Fig 8
Characterizing how wind-up phenomenon changes with frequency.
A: The mean of the average firing rate of P neurons during the C-response (which we define as the time interval 90-300 ms after the start of the stimulus, see blue box on bottom of Fig 6) for each stimulus index increases as a function of the stimulus frequency. B: Latency, defined here as the first time when the average firing rate of P population exceeds the threshold of 25 Hz (interpreted as painful), decreases with the change in the frequency of the repeated stimulus.