Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma
Fig 8
Enrichment of significant S-M interconnections by successive filtering during the development of the signaling-metabolic pathway network.
The successive reduction of non-significant nodes and paths was followed for the inter-connection of the NOTCH pathway to all metabolic pathways. (A) Starting signaling-metabolic interaction network (SMIN) with the NOTCH pathway proteins in purple; (C) to GBM-specific network, and (E) the final GBM-specific significant (Z≥1) network. (B) Connections formed through twelve TOP Perturbation Impact (PI) nodes (red color) for NOTCH to all metabolic in SMIN; (D) connections formed through 11 nodes (in red color; out of 12 genes/proteins found with significant perturbation impact [PI]) in GBM-specific network and (F) connections formed through 9 nodes (in red color; out of 12) in the GBM-specific significant (Z≥1) network.