Connecting signaling and metabolic pathways in EGF receptor-mediated oncogenesis of glioblastoma
Fig 7
Importance of the individual nodes in signaling-metabolic pathway interconnection.
(A) Each of the 654 nodes of the final network was tested in perturbation studies by removing it and its associated connections from the network and recalculating all network parameters. The scores for significant SM pairs (Z≥1) and interconnected paths (path score ≥80% from the highest path score for each SM pair) were redefined for each signaling to all metabolic interconnections. The differences of the sums of all significant path scores before and after perturbation of the individual 654 nodes for each signaling to all metabolic pathway interconnections were converted to Z scores (blue dots) and plotted against the genes/nodes. (B) Summary of the nodes with a significant impact on the entire network. Nodes with significantly altered Z score after perturbation (-2≥Z ≥2) were considered as effective nodes with significant impact and are listed in S3 Table for all interconnections of the 14 signaling pathways to the 6 metabolic pathway groups and vice versa, the metabolic pathway groups to the signaling pathways. Drugable node/proteins according to the KEGG database are highlighted.