Systematic discovery of the functional impact of somatic genome alterations in individual tumors through tumor-specific causal inference
Fig 8
TCI predicts the SGA-FIs and their functional impact at the individual tumor level.
A. A graph produced by TCI for tumor TCGA-B1-A657 that predicts major SGA-FIs and their regulated cancer processes. Blue nodes represent SGA-FIs and red nodes (squares) represent oncogenic processes. An green directed link indicates that TCI predicts that the SGA-FI at the tail of tha arrow regulates 10% or more of the DEGs in the cancer process at the head of the arrow. B. Same DEGs regulated by distinct SGA-FIs in different tumors. DEGs in cancer processes shared between tumor TCGA-B1-A657 and tumor TCGA- HE-A5NL are shown as pie-charts. Blue nodes denote SGA-FIs in tumor TCGA-B1-A657. Red nodes denote SGA-FIs in tumor TCGA- HE-A5NL. Yellow nodes, (i.e., NEFH), are shared by both tumors. Each large node in the middle represents an oncogenic process. Within the circular nodes in the middle of the figure, the number in the purple area denotes the number of DEGs specific to TCGA-B1-A657. The number in the red area denotes the number of DEGs specific to TCGA- HE-A5NL. The number in the yellow area denotes the number of DEGs shared by both tumors. An green directed link indicates an SGA-FI regulates 10% or more DEGs in the cancer process.