A multi-scale model of gas transport in the lung to study heterogeneous lung ventilation during the multiple-breath washout test
Fig 8
N2 washout for regional and local distribution of compliance modifications.
Results of the simulated N2 gas washout for regional and local trumpet lobule compliance modifications. In both cases, the lobular compliance was altered using ϕ = 0.5, and ϕ = 1.5 each for 25% of all trumpet lobules. Normalized phase III slope sIII are shown for the first (a) and last (b) breath. The washout (c, d) for 50 simulated breaths, where only N2 end-expiratory concentrations (symbols) and the corresponding fitting function (dashed line, Eq 13) are shown for better visibility.