Multiscale model of integrin adhesion assembly
Fig 6
Actin architecture does not impact integrin clustering and ligand binding but changes the physical distribution of integrins in adhesions.
(A-C) Snapshots from the simulations: random, crisscrossed and bundled actin networks above a layer of integrins. Filled circles indicate clustered integrins; empty circles indicate ligand-bound integrins. (D) Average percentage of ligand-bound integrins with respect to increasing amount of β-1 integrins (using EIL = EII = 9 kBT) at varying actin architectures. (E) Corresponding percentage of clustered integrins. (F) Distribution of average nearest neighbor distances between ligand-bound integrins using 50% β-1 integrins at varying actin architectures. Results are computed as averages between 20–30 s of simulation.