Multiscale model of integrin adhesion assembly
Fig 1
Both β-1 and β-3 integrins localize at the cell periphery, where nascent adhesions assemble.
(A) Cartoon representation of active, fully extended αIIBβ3 integrin, which is closely related to αvβ3 [82]. (B) Representative images of human foreskin fibroblasts (HFF) fixed after 60 minutes of spreading on fibronectin coated glass coverslips and immunostained for actin and either β-1 or β-3 integrins.