Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks
Fig 6
External stimuli that cause a switch from Th17 to Treg where in this figure we calculated with Algorithm 1 further external stimuli that support the desired switch caused by the external stimuli depicted in Fig 5 where u4 activates IL-2, u7 activates TGF-β, u8 inhibits RORγt, u9 inhibits IL-6 and u10 inhibits IL-6R.
The time is on the abscissa (t) and the activity level (A) on the ordinate. The original Matlab output is without axis labeling.