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Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks

Fig 5

External stimuli that cause a switch from Th17 to Treg where in this figure there is a minimal set of external stimuli that performs the desired switch calculated by Algorithm 3 where u4 activates IL-2, u7 activates TGF-β andu8 inhibts RORγt.

The time is on the abscissa (t) and the activity level (A) on the ordinate. The original Matlab output is without axis labeling.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1007075.g005