A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data
Fig 4
Translation-initiation rates measured using Eq (4) reproduce previously reported correlations with molecular properties.
In vivo translation-initiation rates of S. cerevisiae transcripts are plotted against the inverse of their CDS length, folding energy of mRNA molecule near the 5′ cap and protein copy number in (A), (B) and (C), respectively. (D) The copy number of S. cerevisiae proteins are plotted as a function of the product of the initiation rate of the transcripts that encode them and that transcript’s copy number in a cell. (E) mRNA copy number is plotted against the translation-initiation rate.