Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions
Fig 5
Radial distribution functions of different lipid chains around the centers of mass of four representative proteins.
Leftmost column: RDF plots. The distance was measured in the membrane plane, and the last 500 ns of the simulations were used in the analysis. The gmx rdf tool was used. Error bars show standard error. The dashed line shows the approximate position of the protein surface. Two rightmost columns: Protein structures used in the solvation simulations, as well as snapshots of them residing in the membranes. For membranes, only fatty acid chains are rendered with the protein. The coloring is as follows: blue for saturated chains (both DPPC chains and the stearic acid chain of SDPC), red for monounsaturated chains (both DOPC chains), yellow for diunsaturated chains (both DLiPC chains), green for polyunsaturated chains (docosahexaenoic acid chain of SDPC), and orange for cholesterol.