Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions
Fig 3
The effect of SDPE on the free energies of transfer of proteins between the Lo and Ld phases.
A) Values for A2AR are shown in black solid line. A negative sign of the free energy of transfer indicates A2AR to favor the Ld phase. Inset shows the free energy changes and
of the alchemical transformations (DSPC→DOPC) with and without A2AR, respectively. B) Free energies of all studied proteins in the absence and presence (16 mol%) of SDPE. The more realistic membrane compositions are denoted with “real.”.