Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions
Fig 2
Average 2nd rank acyl chain order parameters (Sn).
A) Average order parameter of the mutated lipid (DSPC→DOPC) in (top) the system containing A2AR, and (bottom) the protein-free system. The cholesterol content was 20 mol% in all systems. The Lo→Ld transformation takes place as the coupling parameter λ changes from zero to one. In Section B.1 in the S1 File, we demonstrate that these end points indeed correspond to the Lo and Ld phases. Error bars showing standard error are smaller than the marker size. B) Effects of SDPE and A2AR on average 2nd rank acyl chain order parameters (). Data are shown for both coarse-grained and all-atom (fine-grained) simulations. For the latter, the order parameter is estimated from the average deuterium order parameter as
, and the error bars show the standard error.