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LASSI: A lattice model for simulating phase transitions of multivalent proteins

Fig 10

Architecture of an archetypal branched multivalent system.

(a) Schematic to depict the overall architecture. The pentamer with 10 orange stickers represents the N130 molecule where the gray central oligomerization domain is modeled as a neutral spacer monomer, and the rpL5 peptide is modeled as a linear molecule with 2 blue stickers. (b) Relevant length scales for the architecture (see also Table 1). For the rpL5 molecule a linker length of 3 was chosen between the two stickers, and for the N130 molecule the first sticker (modeling the A1 tract) is 1 lattice site away from the hub spacer whereas the second sticker (modeling the A2 tract) is 3 lattice sites away from the first sticker.

Fig 10

doi: https://doi.org/10.1371/journal.pcbi.1007028.g010