< Back to Article

LASSI: A lattice model for simulating phase transitions of multivalent proteins

Fig 7

Phase behavior of the linear multivalent systems.

(a, b) Phase diagrams for the A_n+B_n and A_n-B_n systems, respectively. The purple line is a 2-dimensional linear interpolation for = 0.025, and the area encapsulated by the purple line are where the systems have large density inhomogeneities and are thus considered to be phase separated. The green line is a 2-dimensional linear interpolation for ϕ_c = 0.5 and thus is the proxy for the percolation line. (c, d) and ϕ_c curves as a function of concentrations at T* = 0.383 (solid lines in (a) and (b)). (e) Width of the two-phase regime, w(T*), as a function of the reduced temperature. Not only does the A_n-B_n system have a higher critical temperature (T* ~ 0.6 vs. T* ~ 0.4), but also has a wider two-phase regime than the A_n+B_n system.

doi: https://doi.org/10.1371/journal.pcbi.1007028.g007