Reward-driven changes in striatal pathway competition shape evidence evaluation in decision-making
Fig 4
Striatal pathway dynamics and behavioral effects of reward probability in full CBGT network.
A: Time courses show the average population firing rates for L (black) and R (red) dMSNs (top) and iMSNs (bottom) over the the trial window. Shaded areas reflect 95% CI. Colored vertical lines depict the average RT in the low (blue), medium (cyan), and high (yellow) reward conditions. B and C: Summary statistics of dMSN and iMSN population firing rates were extracted on each trial and later included as trialwise regressors on parameters of the DDM, allowing specific hypotheses to be tested about the mapping between neural and cognitive mechanisms. In B, lighter colored bars show the difference between dMSN firing rates in the L and R action channels whereas darker colored bars show the difference between dMSN and iMSN firing rates in the L action channel. Each was computed by averaging normalized values of trialwise estimates of the area under the appropriate firing rate curve (AUC); see main text for details. In C, lighter colored bars show the difference between iMSN firing rates in the L and R action channels and darker colored bars show the average iMSN firing rate (combined across left and right channels). Error bars show the bootstrapped 95% CI. D: Average accuracy (probability of choosing L) and RT (L choices only) of CBGT choices across levels of reward probability. E: RT distributions for correct choices across levels of reward probability; note that higher reward yields more correct trials. Error bars in B-D show the bootstrapped 95% CI.