MAPS: Model-based analysis of long-range chromatin interactions from PLAC-seq and HiChIP experiments
Fig 5
Cis-regulatory elements are enriched in the target bins of MAPS-identified “XOR” interactions.
As only interactions from the “XOR” set are considered, CTCF enrichment analysis is not applicable for mESC CTCF PLAC-seq data, H3K4me3 enrichment analysis is not applicable for mESC H3K4me3 PLAC-seq data, and H3K27ac enrichment analysis is not applicable for GM12878 H3K27ac HiChIP data (denoted as N.A. in the heatmap). For each ChIP-seq/ATAC-seq data, we calculated the proportion of target bins and control bins containing ChIP-seq/ATAC-seq peaks, defined as %target and %control, respectively. We further defined the enrichment score as the ratio between %target and %control (numbers in S9 Table).