Finding driver mutations in cancer: Elucidating the role of background mutational processes
Fig 6
Codon mutability of missense mutations grouped by their experimental effects.
(A) Mutations from the combined dataset were categorized as neutral and non-neutral. Significant differences with p < 0.01 are marked with a double asterisk. Mutability was calculated with pan-cancer background model (B) Mutations binned by their reoccurrence frequency in both MSK-IMPACT (green) and COSMIC v85 (blue) cohorts. In both cohorts, reoccurrence frequency of neutral mutations depends on mutability, whereas for non-neutral mutations, reoccurrence frequency does not scale with background mutability.