Finding driver mutations in cancer: Elucidating the role of background mutational processes
Fig 4
Relationship between codon mutability and frequency of mutations.
Histograms show the Spearman rank correlation coefficients between the reoccurrence frequency and mutability across cancer genes with at least 10 observed mutations of each type: (A) missense (blue), (B) nonsense (red) and (C) silent (green). Filled bars in the left column denote genes with significant correlation at p < 0.01. Bar graphs show Spearman correlation coefficient for genes with significant correlation at p < 0.01. Genes with bold font are tumor suppressors (TSG), underlined genes are oncogenes, and genes in plain font were either categorized as both TSG and oncogene or fusion genes. (D-F) Scatterplots with regression lines and confidence intervals show the linear relationship between mutability and reoccurrence frequency of each type of mutation for several representative genes. Adjusted R2 are shown to convey goodness of fit. Mutation reoccurrence frequencies were taken from the pan-cancer COSMIC v85 cohort.