Finding driver mutations in cancer: Elucidating the role of background mutational processes
Fig 2
Relationship between cancer-specific nucleotide mutability and observed reoccurrence frequency of all mutations from two cohorts.
Counts are binned and refer to how many times a particular mutation was observed in the given cancer type. ‘0’, ‘1’, ‘2’ and ‘3+’ refer to mutations that were not observed (including all possible point mutations), observed once, twice, or in three or more cancer samples. Blue boxes show mutations with the observed frequency calculated in the COSMIC v85 cohort and green boxes refer to MSK-IMPACT cohort. (A) breast cancer (nCOSMIC = 1,667, nMSK = 783 samples), (B) Lung adenocarcinoma (nCOSMIC = 301, nMSK = 1,203), (C) Colon adenocarcinoma (nCOSMIC = 369, nMSK = 688) and (D) Skin malignant melanoma (nCOSMIC = 376, nMSK = 182).