Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
Fig 1
(A) Homology model of AB1 antibody with VH (blue) and VL (green) domains, annotated with the model-predicted accuracy on the CDR H3 at ≤2.5 Å. (B) Structure of muCCL20 showing human and murine sequence differences (grey). (C) VH (blue) and VL (green) sequences of anti-muCCL20 antibody AB1.