A system-wide network reconstruction of gene regulation and metabolism in Escherichia coli
Fig 8
Key elements of the integrative E. coli network.
Key elements with respect to degree (DC) and betweenness centrality (BC) are listed according to their rank as well as their functional characteristic and cross-systemic property, respectively. Open squares denote trivial compounds and filled squares indicate currency metabolites. The colored arrows depict the cross-systemic contribution—downwards interface-related (▼), upwards interface-related (▲). The orange arrows emphasize the cross-systemic components with significant low intra-domain degree fraction and the golden ones point out elements indirectly linking to one of the major traversing paths systems.