A system-wide network reconstruction of gene regulation and metabolism in Escherichia coli
Fig 7
Classical representation of the three major interface systems of the integrative E. coli network.
The systems shown here are the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS, A), the ribonucleotide reducing system (RNR system, B) and the nitrogen regulation two-component signal transduction system (NtrBC system, C). The edges represent biochemical reactions and the vertices denote the involved compounds and proteins. The reactions and proteins highlighted in dark blue are the most abundant vertices determining nearly half of the traversing paths (Table E in S1 Text).