TASmania: A bacterial Toxin-Antitoxin Systems database
Table 3
Granularity of the traditional TAS annotations.
Example of M.tuberculosis H37Rv with some so-called VapB.VapC TA pairs. We propose a more objective nomenclature of the TAS based on the HMM profiles clusters. Note that all VapCs shown here have a PIN Pfam annotation, however their TASMANIA.Tn (Tn) is split into multiple sub-clusters emphasizing the diversity of the PIN domains. In contrast, their associated so-called VapB-like antitoxins have very diverse Pfam annotations, but consistent TASMANIA.An (An) clusters.