Model-based analysis of influenza A virus replication in genetically engineered cell lines elucidates the impact of host cell factors on key kinetic parameters of virus growth
Fig 2
Intracellular replication dynamics in response to in silico modifications of host cell gene expression in a single infected cell.
Changes in levels of viral cRNA (column 1), vRNA (column 2), mRNA (column 3) and matrix protein 1 (M1, column 4) are shown for a simulated infection at MOI 1 for the parental A549 cell line (blue solid line) or upon targeting selected steps of virus replication, as indicated on the left-hand side, by either knockdown (brown solid line) or overexpression (green dashed line).