Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
Fig 14
Sketch of proposed distribution of pacemaker and non-pacemaker neurons within the pre-BötC as well as the the direction and depth of TTX and RZ penetration in thick and thin in vitro slice preparation containing the pre-BötC.
The direction of diffusion and maximal diffusion depth in the thin and thick slice sketches are indicated by arrows and vertical dashed lines. Notice that in a thick slice non-pacemaker neurons are affected first and TTX and RZ fail to fully penetrate the thick slice.