Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
Fig 13
Predicted effect of blockade of INaP in the intact network.
Relative effects of “complete” blockade of INaP by simulated (A) TTX and (B) RZ application on the amplitude (left) and frequency (right) as a function of tonic excitatory drive (gTonic) and the strength of post-I inhibition. Oval shape indicates parameters capable of matching the maximal relative changes in amplitude and frequency seen with experimental application of RZ. The points labeled C and D indicate the gTonic and post-I inhibition values used in panels C and D. (C) Comparison of experimental and simulated RZ blockade of INaP. Simulated RZ application closely matches experimental data when gTonic = 0.4 and post-I inhibition = 0.82. Experimental data is adapted from [13]. (D) Predicted effect of experimental TTX blockade of INaP in the intact network under identical conditions to panel C.