Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
Fig 10
Simulated progressive nonuniform INaP block in the isolated pre-I network.
(A,B,C) From left to right: network burst with neurons color-coded as pacemakers (red) or non-pacemakers (blue) and numbered based on order affected from 1 (first affected) to 50 (last affected); amplitude and frequency of isolated pre-I population oscillations as a function of the percentage of the pre-I population where INaP is completely blocked. For a given neuron, INaP is considered completely blocked when gNaP = 0 nS in the case of TTX (A1,B1,C1) or when Δh1/2 = −15 mV and ISynE is attenuated by 25% for RZ (A2,B2,C2), see Figs 2 and 8. Error bars in C1 and C2 indicate the ±SEM of ten trials where INaP is progressively blocked across the network in random order.