Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
Fig 3
Activity patterns in a model pre-BötC neuron as a function of tonic excitatory synaptic drive (gTonic) and (A) level of gNaP and (B) Δh1/2, which are reduced to simulate TTX and RZ block of INaP, respectively.
Burst frequency (top) and burst duration (bottom) are indicated by color within the bursting regions. Both TTX and RZ effectively abolish intrinsic bursting (colored region): bursting does not occur for gNaP < 2.7nS nor for Δh1/2 < −8.0mV.