Effects of persistent sodium current blockade in respiratory circuits depend on the pharmacological mechanism of action and network dynamics
Fig 2
Effects of simulated TTX and RZ blockade on INaP under steady-state conditions.
(A1 & B1) Effects of simulated TTX and RZ blockade on voltage-dependent steady-state activation (m∞(V)) and inactivation (h∞(V)) for INaP. Notice that simulated RZ blockade shifts inactivation in the hyperpolarizing direction and simulated TTX blockade induces no change. (A2 & B2) Effect of simulated TTX and RZ blockade on the I-V curves for INaP. Notice that simulated TTX and RZ blockade have nearly indistinguishable effects. (C) Peak INaP current as a function of the extent of simulated TTX and RZ blockade. TTX and RZ blockade are simulated by reducing INaP conductance (gNaP) and shifting its half-inactivation (h1/2) in the hyperpolarizing direction, respectively.