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Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations

Fig 6

Distribution of somatic mutations for breast invasive carcinoma (BRCA) is similar by subtype and stage.

The estimated number of hits is identical for subsets of BRCA samples by (a) subtype and (b) stage.

doi: https://doi.org/10.1371/journal.pcbi.1006881.g006