Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations
Fig 5
Estimated number of hits are moderately correlated to lifetime stem cell division.
Pearson’s linear coefficient = 0.522, suggesting that number of hits may depend on cellular growth characteristics of individual tissues. However, the 95% confidence interval = -0.29–0.90, indicating that the relationship may be coincidental. Estimates for lifetime stem cell divisions were from S1 Table of Ref. (29).